Wine and Ubuntu 14.04LTS

I am NOT new to Ubuntu, Kubuntu, Linuz, Puppy or Mint, Fedora etc etc etc, but I am new to this forum, and I thank you all for all the help you have been.

I have made this observation using Ubuntu over the years. Wine, and now Wine HQ seems to be getting better with age.

I have been able to run about all windows junk in Wine HQ, but USB stuff that hooks to weird things takes more than I know.
Things like GPS toys, quad copters with Gui's and camera's with WIndoze specific hardware.

Any of you all get some of these things to work?